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Small molecule inhibitor of PRC1 E3 ligase activity induces differentiation of leukemia initiating cells [ChIP-seq]

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE123930
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We have developed small molecule inhibitors of PRC1. These inhibitors target PRC1, decrease H2A ubiquitination and differentiation of TEX cells. TEX cells treated with DMSO or 25uM WY332 compound for 6 days followed by immunoprecipitation with anti-H2Aub antibody. ChIP sequencing was performed and analyzed by ActiveMotif.
创建时间:
2021-07-06
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