Gene expression profiling of glucocorticoid receptor signaling in primray prostate cancer associated fibroblasts

Glucocorticoid receptor (GR) has been recently identified as a candidate for acquired anti-androgen and chemotherapy resistance. In order to identify glucocorticoid receptor (GR) targets and studying stromal GR signaling gene expression profiling was performed in primary prostate cancer associated fibroblasts using different treatments. Primary cancer associated fibroblasts (PCAF) from 4 prostate cancer patients were treated for 24h in 3 different treatment groups (1 DMSO=Control treatment, 2 Dexamthasone, 3 RU486+Dexamethasone).