Remote Patient Monitoring in Heart Failure: Consistent Evidence for Mortality Reduction — Systematic Review, Meta-Analysis, and Trial Sequential Analysis

Complete data, analysis code, and outputs for a systematic review and meta-analysis evaluating remote patient monitoring (structured telephone support, non-invasive telemonitoring, and invasive hemodynamic monitoring) versus usual care in adults with heart failure. 63 RCTs were identified (57 poolable; ~22,000 participants) from PubMed/MEDLINE, Cochrane CENTRAL, ClinicalTrials.gov, and WHO ICTRP through February 2026. Key findings: All-cause mortality: RR 0.890 (95% CI 0.819–0.966; P=0.007; I²=2.3%; k=41; NNT 84/year) HF hospitalization: RR 0.800 (95% CI 0.729–0.878; P<0.001; I²=45.7%; k=37; NNT 19/year) Trial sequential analysis confirmed firm evidence for the mortality benefit No interaction by RPM type (P_interaction = 0.24–0.34) GRADE: moderate certainty for mortality, low for HF hospitalization Repository contents: Raw database exports and screening data (phases 1–3) Data extraction form (63 studies, 185 variables) with data dictionary R analysis pipeline (15 scripts, fully reproducible) All output figures (forest plots, funnel plots, TSA, RoB) and tables Manuscript source (Rmd), references, and rendering template PROSPERO protocol and search strategies To reproduce: cd scripts/R/ && Rscript run_all.R PROSPERO Registration: CRD420261323628