Campylobacter jejuni RM1246 Sequencing & Assembly

Campylobacter jejuni strain RM1246-ERRC was a kind gift from the laboratory collection of Dr. Robert Mandrell (USDA-WRRC, Albany, CA) and previously labeled as RM1246. This strain originally designated 92A3120 was a clinical isolate derived from a case of human disease by the California State Public Health Lab in Berkeley California (Sharon L. Abbott) and exhibited Penner serotype HS:7. This strain has been utilized in multiple antimicrobial challenge studies. In a recent study the strain exhibited resistance to quaternary ammonium compounds (QACs) in excess of other Campylobacter jejuni strains used in the same study. The genetic material of the strain consists of a chromosome of 1.66 MB and a single plasmid of 45.20 KB in size. The chromosome of the strain possess four separate genes that code for membrane transporters of cationic drugs belonging to the SMR family of proteins. Orthologues of these genes in other species have been shown to be capable of the efflux of QACs.