Stereoselective Synthesis of Isoquinuclidines through an Aza-[4 + 2] Cycloaddition of Chiral Cyclic 2‑Amidodienes
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https://figshare.com/articles/dataset/Stereoselective_Synthesis_of_Isoquinuclidines_through_an_Aza_4_2_Cycloaddition_of_Chiral_Cyclic_2_Amidodienes/2039376
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资源简介：
A highly stereoselective
aza-[4 + 2] cycloaddition of chiral cyclic
2-amidodienes with N-sulfonyl aldimines is described.
While this Lewis acid promoted heterocycloaddition provides an efficient
strategy for constructing optically enriched isoquinuclidines, it
is mechanistically intriguing. The cycloaddition favored the endo-II pathway in the absence of a viable bidentate coordination.
This represents an unexpected switch from the anticipated endo-I selectivity obtained in the all-carbon cycloaddition.
创建时间：
2015-12-17
