Actigraphy and associated data on free-living assessments of movement in people with Amyotrophic Lateral Sclerosis (ALS)

This dataset includes raw and processed actigraphy data collected from individuals diagnosed with Amyotrophic Lateral Sclerosis (ALS), recruited through the Royal Brisbane and Women's Hospital between 2017 and 2021. Participants wore ActiGraph GT9X Link devices on their non-dominant wrist for 8 consecutive days at multiple timepoints over follow-up periods of up to 36 months. The dataset includes summary features derived using ActiLife and the open-source R package GGIR. These features include daily averages of Euclidean Norm Minus One (ENMO), time spent in moderate-to-vigorous physical activity (MVPA), step counts, and peak 6-minute activity measures. Activity count-derived metrics and epoch-level outputs are also provided. Matched phenotypic data includes ALS Functional Rating Scale-Revised (ALSFRS-R) scores and calculated motor subdomains, demographic details (age in years, sex), and durations since disease onset and diagnosis. These covariates are included in accompanying phenotype files to support replication and secondary analyses. The dataset was used to evaluate accelerometer-derived outcomes as candidate digital biomarkers for functional decline, disease monitoring, and powering of clinical trials in MND