RNA-seq of cochlea in mice with a frameshift mutation in the reading frame of thyroid hormone receptor α1. RNA-seq of cochlea in mice with a frameshift mutation in the reading frame of thyroid hormone receptor α1

Thyroid hormone is known to be required for inner ear development. The influence of the thyroid hormone receptor α1 is however unclear, as most previous studies point to a predominant function of the TRβ1/2 isotypes. We report a RNA-seq analysis which completes a full histological and functional analysis showing that mice carrying a mutation of the TRα1 receptor have mild alteration of inner ear. Overall design: Whole inner ear RNA was extracted from heterozygous mutant mice carrying a frameshift mutation which alters the function of TRα1. These RNA were compared to RNA extracted from wild-type littermates.