High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib

High-resolution cryo-EM structure of human Polo-like kinase 1 in complex with onvansertib Descriptor: 1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-2-(TRIFLUOROMETHOXY)PHENYL]AMINO]-4,5-DIHYDROPYRIMIDO[5,4-G]INDAZOLE-3-CARBOXAMIDE, Serine/threonine-protein kinase PLK1 Authors: Park, K, Yoo, Y, Jeon, H, Choi, K, Kwon, E, Lim, H, Kim, D.Y, No, K.T. Deposit date: 2026-01-21 Release date: 2026-04-29 Last modified: 2026-06-24 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: High-resolution cryo-EM structures of small protein-ligand complexes near the theoretical size limit. Nat Commun, 17, 2026