LncRNA CHROME regulates the interferon response to viral challenge [ChIP-Seq]

Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROME. We established that CHROME is most highly transcribed in human macrophages treated with bacterial lipopolysaccharide and RNA viruses. Overall design: We used three replicate samples of THP cells that were treated with gapmer targeting CHROME compared to two replicate control samples. In these cells we performed H3k27ac ChIP-Seq