RNF20 is required for male fertility through H2B ubiquitination in Sertoli cells

Spermatogenesis is an essential process to generate male gametes in vertebrates, and it has become an important social health problem caused by spermatogenesis disorder. However, the molecular mechanism underlying spermatogenesis, particularly epigenetic modification in Sertoli cells of testis, remain elusive. In this study we generated Rnf20 conditional knockout mice by recombinant mothed, and only to find that Rnf20 knockout in Sertoli cells led to male infertility. Comparative gene expression profiling analysis of RNA-seq data for Sertoli cells and testis tissue in WT and Rnf20 conditional knockout mice