RSC and ISW1 Chromatin Remodelers Display Functional and Chromatin-based Promoter Antagonism [HybMap microarray]

ISWI-family chromatin remodelers organize nucleosome arrays, while SWI/SNF-family remodelers (RSC) disorganize and eject nucleosomes, implying an antagonism that is largely unexplored in vivoISWI家族染色质重塑因子（chromatin remodeler）可规整核小体阵列，而SWI/SNF家族染色质重塑因子（RSC）则会解聚并驱逐核小体，这提示二者间存在拮抗作用，而该拮抗作用目前在活体层面尚未得到充分研究。