<b>Molecular mechanism of phenol 2-monooxygenase (FgPhm)</b><b>in regulating virulence and DON biosynthesis in </b><b><i>Fusarium graminearum</i></b>

this study has demonstrated that FgPhm1 is crucial for the growth and development of F. graminearum and the production of Deoxynivalenol (DON), and plays an important role in the pathogenicity and stress response processes of F. graminearum. Through depth research on phenol2-monooxygenase, it lays a foundation for fundamentally revealing the mechanism of action of phenol2-monooxygenase during the growth and development process of F. graminearum, and reveals the relationship between phenol metabolism and the pathogenic mechanism in F. graminearum. Thiswill provides a theoretical basis for the development of new pesticides and the prevention and control of Fusarium head blight of wheat.本研究证实，FgPhm1对禾谷镰孢菌（F. graminearum）的生长发育、脱氧雪腐镰刀菌烯醇（Deoxynivalenol, DON）的合成至关重要，同时在禾谷镰孢菌的致病力与胁迫响应过程中发挥重要作用。通过对苯酚2-单加氧酶（phenol2-monooxygenase）的深入研究，本研究为从根本上揭示该酶在禾谷镰孢菌生长发育过程中的作用机制奠定了基础，并阐明了苯酚代谢与禾谷镰孢菌致病机制之间的关联。本研究可为新型农药的研发以及小麦赤霉病（Fusarium head blight of wheat）的防控提供理论依据。