Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid.
收藏Protein Data Bank Japan2023-10-11 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/6pfd
下载链接
链接失效反馈官方服务：
资源简介：
Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)terephthalic acid. Descriptor: 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)benzene-1,4-dicarboxylic acid, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, Bifunctional dihydrofolate reductase-thymidylate synthase, ... Authors: Czyzyk, D.J, Valhondo, M, Jorgensen, W.L, Anderson, K.S. Deposit date: 2019-06-21 Release date: 2019-10-02 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.324 Å) Cite: Structure activity relationship towards design of cryptosporidium specific thymidylate synthase inhibitors. Eur.J.Med.Chem., 183, 2019
创建时间：
2019-06-21
