Data from: Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization

Aim: Decidualization is essential for embryo implantation and placental
development. We aimed to obtain transcriptome and epigenome profiles for
primary endometrial stromal cells (ESCs) and in vitro decidualized cells.
Materials & methods: ESCs isolated from human endometrial tissues
remained untreated (D0), or decidualized for 4 days (D4) and 8 days (D8)
in the presence of 8-bromo-cAMP and progesterone. Results: Among the
epigenetic modifications examined (DNA methylation, H3K27ac, H3K9me3 and
H3K27me3), the H3K27ac patterns changed most dramatically, with a moderate
correlation with gene expression changes, upon decidualization. Subsets of
up- and down-regulated genes upon decidualization were associated with
reciprocal changes of H3K27ac and H3K27me3 modifications at their promoter
region, and were enriched with genes essential for decidualization such as
WNT4, ZBTB16, PROK1 and GREB1. Conclusion: Our dataset is useful to
further elucidate the molecular mechanisms underlying decidualization.