IL-33 from oligodendrocytes sustains effector differentiation of CD8+ tissue-resident T cells and is a druggable target in CNS autoimmune disease

Our study identifies oligodendrocyte-derived IL-33 as a druggable tissue factor regulating the differentiation and survival of self-reactive CD8+ T cell in the inflamed CNS. This finding introduces tissue factors as a novel category of immune targets for treating chronic CNS autoimmune diseases. Overall design: Transcriptional activity of FACS-sorted brain CD8 GP33-41+ T cells from WT, MOG-GP, and IL-33 cKO MOG-GP mice at 21 days after rLCMV-GP33 infection. Transcriptional activity using scRNAseq of FACS-sorted brain CD45+ cells from MOG-GP, and IL-33 cKO MOG-GP mice at 21 days after rLCMV-GP33 infectionfon.