Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator

Crystal structure of human TEAD2-Yap binding domain covalently bound to an allosteric regulator Descriptor: 1-{4-[4-(trifluoromethyl)anilino]-1,3-dihydro-2H-isoindol-2-yl}propan-1-one, Transcriptional enhancer factor TEF-4 Authors: Bum-Erdene, K, Gonzalez-Gutierrez, G, Meroueh, S.O. Deposit date: 2025-08-14 Release date: 2025-09-03 Last modified: 2026-03-04 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells. Acs Chem.Biol., 20, 2025