Vitamin C deficiency causes cell type-specific epigenetic reprogramming and acute tubular necrosis
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE190371
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资源简介：
The recently described roles of vitamin C as an epigenetic regulator playsa crucial role in normal physiological development and pathological conditions.However, the epigenetic regulatory role of vitamin C in renal homeostasis andpathogenesis remains largely unknown. We aim to reveal that vitamin C deficiency promoted acute tubular necrosis,and provide a potential mechanism for epigenetic therapy in preventing the progression of chronic kidney disease. scRNA-seq, WGBS and MeRIP-seq profiles of wild type (WT) and Gulo-/- mice
创建时间：
2021-12-11
