Data from: Pathology in repeated transurethral resection of a bladder tumor as a risk factor for prognosis of high-risk non-muscle-invasive bladder cancer

The prognostic value of repeat transurethral resection of bladder tumor
(TURBT) in patients with diagnosed high-risk, non-muscle-invasive bladder
cancer (NMIBC) was investigated. We retrospectively reviewed the medical
records of patients treated from October 2004 to December 2013 at Seoul
National University who underwent repeated TURBT within 2–6 weeks after an
initial resection. The study enrolled patients who had been diagnosed with
NMIBC at both the initial and repeat TURBT; patients with muscle-invasive
tumors on repeat TURBT were excluded. We used stepwise multivariate Cox
regression models stratified by study to assess the independent effects of
the predictive factors and estimated hazard ratios (HRs) from the Cox
models. We investigated a total of 198 patients who were diagnosed with
high-risk NMIBC. In logistic regression analyses, number of bladder tumors
(2–7: OR, 2.319; 8≤: OR, 3.353; p<0.05), initially high tumor grade
(OR, 2.435; p = 0.040), and presence of carcinoma in situ lesion (OR,
3.639; p = 0.017) correlated with residual tumor in the repeated-TURBT
specimen. T1 stage in repeated-TURBT significantly correlated with
recurrence (HR, 1.837; p = 0.010) and progression (HR, 2.806; p = 0.029)
in multivariate analysis. The high grades of tumors in repeated-TURBT also
significantly correlated with progression but not recurrence in the
multivariate analysis (HR 2.152; p = 0.008). In this study, the pathologic
findings in repeated-TURBT correlated with recurrence and progression in
high-risk NMIBC. Repeated-TURBT is valuable because it can predict the
recurrence and progression of high-risk NMIBC in addition to obtaining
accurate pathologic findings.