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Candidate human ADAR-targeting guide RNA off-target analysis data.

Figshare2025-02-24 更新2026-04-28 收录

数据链接：

https://figshare.com/articles/dataset/Candidate_human_i_ADAR_i_-targeting_guide_RNA_off-target_analysis_data_/28474631 数据链接链接失效反馈

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资源简介：

Candidate human ADAR-targeting guide RNA off-target analysis data.

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创建时间：

2025-02-24

通用型CAR-T疗法

基因编辑安全性

Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies. However, the generation

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Cas12a base editors induce efficient and specific editing with low DNA damage response (DNA targeted sequencing)

CRISPR碱基编辑优化

基因编辑安全性

The advent of base editors (BEs) holds a promising potential in correcting pathogenic-related point mutations to treat relevant diseases. Unexpectedly, Cas9 nickase (nCas9) derived BEs lead to DNA dou

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Off-target sequencing for IL2RG gRNA in human cells

CRISPR脱靶检测

基因编辑安全性

Off-target sequencing for IL2RG gRNA in human cells.Includes: 1) GUIDE-seq in HEK293-Cas9 cells, and 2) rhAmpSeq in HEK293-Cas9 + CD34+ HSPCs.

NIAID Data Ecosystem10

DNA Nicks Promote Efficient and Safe Targeted Gene Correction

靶向基因校正

基因编辑安全性

Targeted gene correction employs a site-specific DNA lesion to promote homologous recombination that eliminates mutation in a disease gene of interest. The double-strand break typically used to initia

NIAID Data Ecosystem30

High-throughput imaging of CRISPR- and rAAV-induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells

基因编辑安全性

高通量筛选

CRISPR-Cas technology has revolutionized gene editing, but concerns remain due to its propensity for off-target interactions. This, combined with genotoxicity related to double-strand breaks more gene

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Candidate human ADAR-targeting guide RNA off-target analysis data.

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