生长分化因子1诱导的肿瘤可塑性为肝细胞癌的免疫治疗提供了治疗窗口
收藏干细胞与再生医学数据中心2023-02-10 更新2024-03-06 收录
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Poorly differentiated hepatocellular carcinoma (HCC) is an aggressive disease with poor prognosis. Here the authors show that GDF1, a member of the TGF-β superfamily, is highly expressed in high-grade poorly differentiated HCC and is associated with tumor plasticity, and that GDF1-induced re-expression of cancer testis antigens could render tumors sensitive to immune checkpoint inhibition.
创建时间：
2023-02-10
