G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT [Run2943]. G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS, REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT [Run2943]

Study the impact of IDH1 mutation in glioma on the tumor infiltrating myeloid cells phenotype and function Overall design: Identification of the tumor-infiltrating myeloid cell's heterogeneity in genetically engineered glioma animal model expressing wild-type IDH or mutant IDH