Additional file 1: of Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions

Sheet 1: Reactions in iEK1011 and details of reactions. Sheet 2: Metabolites in iEK1011 and details of metabolites. Sheet 3: Genes present in previous models but not accounted for in iEK1011. Sheet 4: Gene Essentiality Predictions with the Griffin et al. dataset. Sheet 5: Gene Essentiality Predictions with the deJesus dataset. Sheet 6: Description of media conditions used in study. Sheet 7: Maximum FVA values for AMR genes across different objectives on in vivo media. Sheet 8: Maximum FVA values for AMR genes across different objectives on in vitro media. Sheet 9: “Shared” Essentiality Predictions with the Griffin et al. dataset. Sheet 10: “Shared” Essentiality Predictions with the deJesus et al. dataset. Sheet 11: List of blocked reactions in iEK1011. Sheet 12: “All models incorrect” - List of genes that were incorrectly predicted across all models and their corresponding iEK1011 subsystems. Sheet 13: “iEK Wrong and sMtb Correct” - List of incorrect iEK1011 predictions that were correctly predicted by sMtb. Sheet 13: “iEK Correct and sMtb Wrong” - List of correct iEK1011 predictions that were incorrectly predicted by sMtb. (XLSX 258 kb)