Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Possesses Selective Estrogen Receptor Degrader Activities
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated Lasofoxifene Derivative that Possesses Selective Estrogen Receptor Degrader Activities Descriptor: (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor Authors: Hosfield, D.J, Greene, G.L, Fanning, S.W. Deposit date: 2022-03-31 Release date: 2022-06-15 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022
创建时间：
2022-03-31
