Identification of differentially expressed miRNAs in exosomes secreted from human colon cancer stem cells.. Identification of differentially expressed miRNAs in exosomes secreted from human colon cancer stem cells.

As accumulating evidence suggests cancer cells exhibit stem-like properties for advanced diseases and cancer stem cells (CSCs) have been identified in various tumor types, revisiting present knowledge toward CSCs is essential. The identification of exosome-loaded miRNAs responsible for stemness and chemoradioresistance of CSCs should eventually leadd to development of novel therapeutic approaches. Overall design: Expression profiles of miRNAs of purified exosomes from parental HCT15/29 cells and HCT15/29-derived cancer spheres were generated for identifying central miRNAs for CSC malignancy.