Locus folding mechanisms determine modes of antigen receptor gene assembly

NIAID Data Ecosystem2026-05-01 收录

免疫基因重组

V(D)J重组

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE249649 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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2024-04-05

The RAG-HMG1 Complex Enforces the 12/23 Rule of V(D)J Recombination Specifically at the Double-Hairpin Formation Step

V(D)J重组

淋巴细胞受体基因重组

A central unanswered question concerning the initial phases of V(D)J recombination has been at which step the 12/23 rule applies. This rule, which governs which variable (V), diversity (D), and joinin

PubMed Central70

NUDCD3 deficiency disrupts V(D)J recombination to cause SCID/Omenn syndrome

先天性免疫缺陷疾病

V(D)J重组

Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 9 affected patients across 3 consanguineous kindreds, we detec

NIAID Data Ecosystem40

Association of terminal deoxynucleotidyl transferase with Ku

V(D)J重组

DNA损伤修复蛋白

Terminal deoxynucleotidyl transferase (TdT) catalyzes the addition of nucleotides at the junctions of rearranging Ig and T cell receptor gene segments, thereby generating antigen receptor diversity. K

PubMed Central1999-11-23 更新20

Igk locus capture-based target enrichment sequencing. Igk locus capture-based target enrichment sequencing

V(D)J重组

DNA双链断裂修复

Cell cycle is a major determinant of DNA double-strand break (DSB) repair pathway choice with homologous recombination (HR) that is most active in S phase cells and non-homologous end-joining (NHEJ) t

NIAID Data Ecosystem50

J region use by V14: comparison between experimental and simulation data.

V(D)J重组

*Frequencies of rearrangements of V14 genes were calculated from Figure 2 in Aude-Garcia et al.[10], for the combinations with three J panels, corresponding to series of J genes scattered along the J

NIAID Data Ecosystem30

Locus folding mechanisms determine modes of antigen receptor gene assembly

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