Expression profile of DNMT1 KO and DNMT1 L1TD1 HAP1 cells by high throughput sequencing

In this study, we aimed at analyzing gene expression profile of DNMT1 KO and DNMT1 L1TD1 DKO HAP1 cells using high throughput sequencing. Our study reveals a comprehensive analysis of differentially expressed transcripts in the absence of L1D1. To delineate the role of of L1TD1 in HAP1 cells, we deleted L1TD1 in DNMT1 KO background as WT HAP1 cells do not express L1TD1. We analyzed differentially expressed transcripts in DNMT1 KO with respect to the negative control DNMT1 L1TD1 DKO HAP1. the experiment included biological triplicates for each genotype.