Development of NUP98-HOXA9 gene expression signatures. Homo sapiens

To explore the molecular mechanisms induced by the leukemic fusion protein NUP98-HOXA9, we performed gene expression analysis of human hematopoietic progenitors and primary samples of patients that express NUP98-HOXA9. By combining these data with ChIP-seq results, we observed that the fusion protein is able to both activate and repress the expression of its target genes. Overall design: Three independent experiments were performed using different clones of the human hematopoietic progenitor model (hHP-NH) and control model (hHP-empty vector). On the other hand, RNA from seven primary samples was analyzed.