RNA-seq of C3H/He mice on the American Lifestyle diet (ALIOS)

We have developed a novel murine model of Diet-induced HCC via feeding the C3H/He mouse strain with the American life style diet (ALIOS) for 48 weeks. RNAseq was performed to the developed tumors as well as the non-tumor tissue of mice livers seeking for understanding the contributing pathways to the development and the progression of HCC in this mice strain. We also investigated whether the tumors developed in mice recaptiulate any particular human HCC subclass. Overall design: RNA-seq of non-tumor and tumor tissues of mice fed on Amercan lifestyle diet and control diet with/without concurrent admistration of the liver carcinogen DEN