Remote Stereoinductive Intramolecular Nitrile Oxide Cycloaddition: Asymmetric Total Synthesis and Structure Revision of (−)-11β-Hydroxycurvularin
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https://figshare.com/articles/dataset/Remote_Stereoinductive_Intramolecular_Nitrile_Oxide_Cycloaddition_Asymmetric_Total_Synthesis_and_Structure_Revision_of_11_Hydroxycurvularin/3045655
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资源简介：
The first total synthesis and structure
revision of (−)-11β-hydroxycurvularin
(1b), a macrolide possessing a β-hydroxyketone
moiety, were accomplished. The β-hydroxyketone moiety in this
natural product was introduced by cleavage of the N–O bond
in an isoxazoline ring that was formed diastereoselectively in a 1,5-remote
stereocontrolled fashion by employing intramolecular nitrile oxide
cycloaddition.
创建时间：
2016-03-14
