RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and ERBB2 homodimer:p-SHC1

Based on activation of RAS signaling by autophosphorylated ERBB2 homodimers, as well as binding of GRB2 and SHC1 to ERBB2 homodimers (Pickl and Ries 2009), it is assumed that SOS1, recruited to ERBB2 homodimers through GRB2, mediates GDP to GTP exchange on RAS protein family, resulting in formation of the active RAS:GTP complex.

基于自磷酸化ERBB2同源二聚体的RAS信号通路激活，以及GRB2和SHC1与ERBB2同源二聚体的结合（Pickl和Ries，2009年），据此推测，SOS1通过GRB2招募至ERBB2同源二聚体，介导RAS蛋白家族中的GDP与GTP交换，从而形成活性RAS:GTP复合物。