Gene-Environment Interactions in COCCaINE Use Disorder: Collaborative Case-Control Initiative in Cocaine Addiction

Drug addiction is a phenotype that has high heritability estimates. In recent years, association studies of candidate genes and some genome-wide association studies (GWAS) have identified a large number of SNPs associated with substance use, abuse or dependence, particularly in phenotypes related to alcohol and nicotine use. Regarding snorted or smoked cocaine dependency, only one GWAS has been conducted so far. In addition, genetic association studies that specifically evaluated smoked cocaine dependence (e.g. crack) are rare, because of characteristics related to the route of administration and duration of the effect of the drug. Thus, the main aim of this GWAS was to identify genetic variations that modulate the risk for the cocaine dependence.]]>
Following is inclusion criteria for cases: 18 to 70 years of age diagnosed according to DSM-IV criteria for current cocaine use disorder reporting recent cocaine use able to understand the consent form and provide written informed consent Following is exclusion criteria for cases: severe and unstable medical disorder Following is inclusion/exclusion criteria for controls: The same inclusion/exclusion criteria were applied for controls, except control participants were excluded if they were diagnosed for any substance use disorder, with the exception of tobacco. ]]>
2010 - first qualifying visit 2011 - first blood drawn for genetic studies with clinical data collection (female subjects) 2015 - first blood drawn for genetic studies with clinical data collection (male subjects) ]]>