Comparison of small cell lung cancer PDX model FHSC04 for response to LSD1 inhibitor RG6016/ORY1001
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103096
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The goal of this study was to understand how the LSD1 inhibitor RG6016/ORY1001 leads to selective efficacy in subsets of small cell lung cancer. SCLC cell lines, PDX models studied ex vivo and studied in vivo were employed in this analysis SCLC PDX model was propagated into 10 immunocompromised NSG mice. 5 were treated with saline vs. 5 with 400ug/kg RG6016/ORY1001 orally on day 0,7 and 4 hours before collection on Day 10. Tumor RNA was isolated and RNA-seq analyses performed
创建时间：
2021-07-25
