Synthesis of Novel C6-Phosphonated Purine Nucleosides under Microwave Irradiation by SNAr−Arbuzov Reaction

Novel C6-phosphonated purine nucleosides were obtained
in good to excellent isolated yields by the simple and catalyst-free SNAr−Arbuzov reaction of trialkyl phosphite with
6-choloropurine nucleosides, including a series of nonsugar
carbon nucleosides. Shorter reaction times were needed, and
substantially higher yields were obtained under microwave
irradiation conditions compared with conventional heating
conditions.

通过一种简便且无需催化剂的SNAr−Arbuzov反应，将三烷基膦酸酯与6-氯嘌呤核苷进行反应，成功获得了一系列C6-磷酰化嘌呤核苷，其孤立产率良好至优秀，其中包括一系列非糖碳核苷。与传统的加热条件相比，在微波辐射条件下，反应时间缩短，且产率显著提高。