RNA binding protein HuR protects against NAFLD by suppressing long noncoding RNA H19 expression

NAFLD has become the most common chronic liver disease worldwide. Human antigen R (HuR), an RNA-binding protein, is an important post-transcriptional regulator. HuR has been reported as a key player in regulating lipid homeostasis in the liver and adipose tissues by using tissue-specific HuR knockout mice. However, the underlying mechanism by which hepatocyte-specific HuR regulates hepatic lipid metabolism under metabolic stress remains unclear and is the focus of this study. Overall design: Comparative gene expression profiling analysis for the livers of wild type mice and hepatocyte-specific HuR knockout mice fed Western Diet and sugar water.