Prolactin EDS-Mogavero et al- raw

Study Objectives were: to identify subjects with hyperprolactinemia in a clinical sample of patients; to separate participants with a complaint of significant excessive daytime sleepiness (EDS) from those without; to compare the neurological and sleep conditions found in patients subgrouped by EDS and hyperprolactinemia; to identify patients with hyperprolactinemia and EDS not supported by the presence of any other neurological or sleep disorder, or substance/medication use. A retro-spective chart review of inpatients was carried out in order to identify all patients in whom the prolactin (PRL) serum levels were determined. A total of 130 subjects were retrieved: 55 had in-creased levels of PRL while the remaining 75 participants had normal PRL levels. EDS was reported by 32 (58.2%) participants with increased PRL and 34 (45.3) with normal PRL. EDS was associated with a sleep or neurological condition in all participants with normal PRL (especially obstructive sleep apnea, 79.4%), but not in those with increased PRL, among whom eight had no other neu-rologic or sleep disorder (or drug) potentially causing EDS and, at polysomnography, had time in bed, sleep period time, and total sleep time longer than those with an associated condition. These findings can be considered as a proof of concept supporting the hypothesis of a role of hyperpro-lactinemia in EDS and represent a basis for future controlled studies able to test in a reliable, ob-jective, and methodologically more appropriate way this hypothesis.

研究目标包括：在临床样本中识别出患有高催乳素血症的患者；将主诉有显著日间过度嗜睡（EDS）的参与者与无此类主诉的参与者区分开来；比较根据EDS和高催乳素血症划分的患者亚组的神经和睡眠状况；识别出那些高催乳素血症和EDS，且无其他神经或睡眠障碍存在，或无物质/药物使用支持的患者。通过回顾性病历审查，确定了所有检测到催乳素（PRL）血清水平的患者。共检索到130名参与者：其中55名患者的PRL水平升高，而其余75名参与者的PRL水平正常。在PRL水平升高的参与者中，有32名（占58.2%）报告了EDS，而在PRL水平正常的参与者中，有34名（占45.3%）报告了EDS。在PRL水平正常的所有参与者中，EDS与睡眠或神经系统状况相关（特别是阻塞性睡眠呼吸暂停，占79.4%），而在PRL水平升高的参与者中则没有，其中8名患者无其他可能引起EDS的神经或睡眠障碍（或药物），且在多导睡眠图检查中，他们的卧床时间、睡眠周期时间和总睡眠时间均长于有相关状况的患者。这些发现可以视为支持高催乳素血症在EDS中起作用的假设的初步证据，并为未来能够以可靠、客观、方法学上更合适的方式测试这一假设的对照研究奠定了基础。