mRNA cap methylation in pluripotency and differentiation
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=6adb630dd27b0f0d56bb55473492cad2
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资源简介：
The mRNA cap recruits factors essential for transcript processing and translation initiation.  We report that regulated mRNA cap methylation is a feature of embryonic stem cell (ESC) differentiation.  Expression of the mRNA cap methyltransferase activating subunit, RAM, is elevated in ESCs resulting in high levels of mRNA cap methylation and expression of Oct4 and Sox2 and other pluripotency-associated factors.  During neural differentiation, RAM is suppressed which is required for loss of Oct4 and Sox2 and correct expression of neural markers.
提供机构：
University of Dundee
创建时间：
2022-02-20
