The causing gene research of Polygonum multiflorum induced liver injury

The incidence of drug induced liver injury (DILI) increased in recent years. Since most DILI are idiosyncratic which has obvious individual differences and genetic predisposition, so research on genetic polymorphism of DILI would help prevent it to happen. Present researches on this respect have preliminary progress, but few genes are clearly related to Polygonum multiflorum-induced liver injury (PM-DILI). This project aimed to identify candidate single nucleotide polymorphism (SNP) for PM-DILI. The data come from whole exome sequencing of 8 PM-DILI patients (BJ01, BJ03, BJ07, BJ08, BJ09, BJ10, 007,008), 4 clarithromycin-DILI patients (BJ02, BJ04, BJ05, BJ06) and 8 healthy controls (211-218).