AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia. AR/miR-221/IGF-1 pathway mediates the pathogenesis of androgenetic alopecia

Our data showed that miR-221 had a profound effect on the biological function of dermal papilla cells (DPCs) and dermal sheath cells (DSCs) of hair follicle. Overexpression of miR-221 affected the MAPK signaling in DPCs, and PI3K/AKT signaling in DSCs. Overall design: The effect of miR-221 overexpression on gene expression profile in cultured DPCs and DSCs