Pathology and Pathways.

Carcinoma in situ (CIS) tumors are best described by relative underexpression of the cell cycle stimulatory (CC+) pathway. This relationship was consistent when taking into account only the presence or absence (+/−) of a CIS component of the tumor as well as the percentage (%) of the tumor that was CIS. Acinar tumors tended to have relative overexpression of the complement and PDGF pathways and relative underexpression of the angiogenesis pathway. Relative underexpression of the CC+ pathway was a strong indicator of papillary tumors as were relative overexpression of the EGFR and hedgehog pathways. Solid tumors were best defined by relative overexpression of the CC+, JAK/STAT and angiogenesis pathways and by relative underexpression of the Notch pathway. NA means the variable was excluded during model selection.