HIF-1 Dependent Genes in ER-negative PyMT Mammary Tumor Cells. HIF-1 Dependent Genes in ER-negative PyMT Mammary Tumor Cells

PyMT cells (HIF-1 wild type, WT and HIF-1 knockout, KO) were compared for differential gene expression at normoxia or after exposure to hypoxia, 0.5% oxygen for 6h Overall design: n=3 HIF-1 WT grown at normoxia, n=3 HIF-1 WT grown at hypoxia, n=3 HIF-1 KO grown at normoxia, n=3 HIF-1 KO grown at hypoxia cultured in DMEM/F12 supplemented with 2% FBS