Correlation between TB manifestations and percentages of CD27lowIFN-γ+ CD4 T cells in the blood of TB patients.

1Analysis was initially performed in 50 patients. Subsequently, 12 patients from validation cohort were added (n = 62), mainly to check the consistency of the results. The results obtained in both cohorts are shown.2Simple correlation analysis selects five major predictors for the accumulation of IFN-γ+CD27low cells in the blood of TB patients (highlighted in bold). For TB duration and Mtb multi-drug resistance p-values were >0.007 (insignificant for multiple (seven) parameter testing); these factors were not included in multiple linear regression analysis. rho, Spearman coefficient, p, significance value of the test.3Multiple linear regression identified lung tissue destruction and clinical TB severity as the main correlates for the accumulation of CD27lowIFN-γ+ cells in the blood of TB patients (highlighted in bold).4NA, not included in multiple linear regression analysis.