Interaction of integrin alphaVbeta3 with PECAM1

Alpha v beta 3 integrin is one of the potential heterophilic ligands of PECAM-1 that is involved in down-regulation of T-cell responses. The heterophilic interaction of alpha v beta 3 integrin on endothelial cells with PEACAM-1 on leukocytes increases the adhesive function of beta integrins on T cells, monocytes, neutrophils and NK cells suggesting that leukocyte PEACAM-1 act as a signaling molecule.

αvβ3整合素作为一种潜在的异源配体，与PECAM-1相关联，并参与调节T细胞反应的降低。αvβ3整合素在血管内皮细胞上的异源相互作用，与白细胞上的PEACAM-1，增强了β整合素在T细胞、单核细胞、中性粒细胞和自然杀伤细胞上的粘附功能，由此推测白细胞上的PEACAM-1充当一种信号分子。