Data and code from: Impact of dosing schedules on performance of rotavirus vaccines in Ghana

There is currently limited evidence regarding how the rotavirus vaccine
dosing schedule might be adjusted to improve vaccine performance. We
quantified and compared the impact of the previously implemented 6/10-week
monovalent Rotarix vaccine in Ghana to the model-predicted impact for
other vaccine dosing schedules across three hospitals and the entire
country. Compared to no vaccination, the model-estimated median percentage
reductions in rotavirus ranged from 28-85% and 12-71% among children
<1 year and <5 years of age, respectively. The median
predicted reductions in rotavirus for the whole country ranged from 57-66%
among infants <1 year and 35-45% among children <5 years of
age. The 1/6/10- and 6/10/14-week schedules provided the best and
comparable reductions in rotavirus compared to the original 6/10-week
schedule, whereas there was no improvement in impact for the 10/14-week
schedule. A third dose could prevent an additional 9-14% of deaths. We
found that administering an additional dose of RV1 might be an effective
strategy to improve rotavirus vaccine impact, particularly in settings
with low vaccine effectiveness.