Top Inhibited Upstream Regulators1.

1Top upstream regulators selected based on p value of overlap and activation Z score. Data were ordered by p value of overlap. If more than 10 pathways were indicated as inhibited for a condition, the top 10 regulators were chosen as the 10 most significant regulators (based on p value) that had a Z score ≤ -2.2Z score infers the activation states of predicted regulators based on expression of the downstream genes within the pathway; A score ≤ -2 indicates inhibition.3P value of overlap evaluates whether there is a statistically significant overlap between differentially expressed genes and the genes that are regulated by the upstream regulator.Top Inhibited Upstream Regulators1.