Dephosphorylation of pL1 (Y1176)

L1 translocated to the non raft membranes of the C-domain is dephosphorylated. A number of potential candidate phosphatases exist including phosphotyrosine phosphatases. Dephosphorylation of Y1176 allows L1 binding to AP-2, an adaptor required for clathrin mediated internalization of L1.

C域的非板层状膜中转移的L1被去磷酸化。存在多种潜在的磷酸酶候选者，包括磷酸化酪氨酸磷酸酶。Y1176位点的去磷酸化使得L1能够与AP-2结合，而AP-2作为一种适配蛋白，对于L1通过网格蛋白介导的内吞作用是必需的。