Novel LncRNA and mRNA expression profiles of peripheral blood mononuclear cells in patients with systemic lupus erythematosus and healthy controls. Novel LncRNA and mRNA expression profiles of peripheral blood mononuclear cells in patients with systemic lupus erythematosus and healthy controls

The multi-system involvement and high heterogeneity lead to great challenge in the diagnosis and treatment of systemic lupus erythematosus (SLE). Long non-coding RNA is a type of RNA greater than 200 nucleotides that does not encode proteins. LncRNA is a key regulator of gene expression in the immune system and is involved in the pathogenesis of a variety of autoimmune diseases, including SLE. In this work, we performed transcriptome sequencing and microarray analysis of peripheral blood mononuclear cells (PBMC) from freshly isolated healthy controls (n=5) and SLE patients (n=5) to analyze the expression of novel lncRNAs and mRNAsand explore their potential as biomarkers and their correlation with clinical features. Overall design: PBMCs were isolated from 5 healthy controls and 5 patients with SLE, and total RNA was extracted for transcriptome sequencing [Dec-28-2022] The submitter corrected the annotation of GSM4962537-GSM4962541 from healthy controls to SLE patients and of GSM4962542-GSM4962546 from SLE patients to healthy controls.