Early programming of CD8+ T cell response by the orphan nuclear receptor NR4A3 [ATAC-Seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE143511
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We analysed the chromatin opening and accessibillity of transcription factor binding motifs of in vitro activated OT-I CD8+ T cells in the absence of NR4A3 to determine the early impact of NR4A3 in CD8 T cell differentiation We isolated naive OT-I CD8+ T cells and stimulated them in vitro for 12h with anti-CD3 and anti-CD28 antibodies. Immediately we isolated the nuclei of stimulated cells and did the tagmentation assay, the isolation of DNA, it's amplification and paired-end sequencing
创建时间：
2020-11-23
