Immune regulatory loops determine productive interactions within human T lymphocyte–dendritic cell clusters
收藏PubMed Central1999-02-16 更新2026-04-25 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC15506/
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资源简介：
Help for the induction of cytolytic T lymphocytes is mediated by dendritic cells (DC) that are conditioned by CD40 signaling. We identified tumor necrosis factor family member CD27L/CD70, which is expressed by cytolytic T lymphocytes on interaction with DC to control CD154 (CD40L) up-regulation on CD45RA(+) helper T cells for subsequent DC stimulation. The results show that the initiation of a cytolytic immune response is determined by regulatory circuits, requiring simultaneous activation and differentiation of all cells involved in T lymphocyte–DC cluster formation.
提供机构：
National Academy of Sciences
创建时间：
1999-02-16
