Comparison of the replication kinetics of individual lineages within an experimental group including the parent virus (Parent), duplicate lineages passaged exclusively in Huh-7 cells (P10 Huh-7) or duplicate lineages passaged in alternation between Huh-7 and C6/36 cells (P10 Alt).

*An arrow in a cell indicates a significant difference between two lineages based on a Tukey-Kramer post-hoc comparison, an empty cell indicates that no significant difference was detected between the lineages. The direction of the arrow indicates the overall progeny production of the first virus in the comparison versus the second virus. Experimental Groups are defined by the virus used to initiate passages, the population of virus, consensus or cloned, used to initiate passages, and the cell line in which the replication curve was conducted.