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Improved RNA base editing with guide RNAs mimicking highly edited endogenous ADAR substrates

NIAID Data Ecosystem2026-05-02 收录

RNA碱基编辑优化

ADAR蛋白

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1163502 数据链接链接失效反馈

官方服务：

资源简介：

high-throughput measurements of gRNA editing efficiencies.

应用场景：

创建时间：

2024-09-20

RNA编辑机制

ADAR蛋白

We report RNA editing changes across the trancriptome in U87 cells that express ADAR3 compared to control cells. Examination of 3 biological replicates of U87 cells expressing ADAR3 compared to contr

NIAID Data Ecosystem60

Robust RNA editing via recruitment of endogenous ADARs using circular guide RNAs

RNA测序技术

ADAR蛋白

We engineered circular ADAR recruiting guide RNAs (cadRNAs) that efficiently recruit endogenous ADARs to edit specific sites on target RNA Overall design: We tested two Circular ADAR recruiting guide

NIAID Data Ecosystem50

Investigating the genetic basis of RNA Editing in humans. Homo sapiens

RNA编辑

ADAR蛋白

Adenosine deaminases acting on RNA (ADAR) are proteins that deaminate adenosine to inosine, which is then recognized by the ribosome as guanosine. To study the genetic basis of RNA editing efficiency

NIAID Data Ecosystem30

Selective Recognition of RNA Substrates by ADAR Deaminase Domains

RNA编辑机制

ADAR蛋白

Adenosine deamination is one of the most prevalent post-transcriptional modifications in mRNA and is catalyzed by ADAR1 and ADAR2 in humans. ADAR1 and ADAR2 have different substrate selectivity, which

NIAID Data Ecosystem50

RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond

RNA表观遗传学

ADAR蛋白

Detect and quantify the changes of RNA modifications in ADAR mouse brainsDOI: “10.1038/s41598-025-30030-4”

DataCite Commons2025-12-03 更新30